" Anti-oxidant and anti-inflammatory effects of the extracts of C. sativus and its constituents (crocetin, crocins, safranal) implies saffron therapeutic potential for various nervous system disorders. Based on the literature, beneficial effects of the plant and its components on neurodegenerative disorders such as Alzheimer and Parkinson's disease are mainly due to their interactions with cholinergic, dopaminergic and glutamatergic systems. It is assumed that saffron anticonvulsant and analgesic properties and its effects on morphine withdrawal and rewarding properties of morphine might be due to an interaction between saffron, GABA and opioid system." *>
" The purpose of this study was to conduct a meta-analysis of published randomized controlled trials examining the effects of saffron supplementation on symptoms of depression among participants with MDD. Based on our pre-specified criteria, five randomized controlled trials (n= 2 placebo controlled trials, n= 3 antidepressant controlled trials) were included in our review. A large effect size was found for saffron supplementation vs placebo control in treating depressive symptoms, revealing that saffron supplementation significantly reduced depression symptoms compared to the placebo control. Findings from clinical trials conducted to date indicate that saffron supplementation can improve symptoms of depression in adults with MDD." * Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials
Topic: Effect of saffron on fluoxetine-induced sexual impairment in men
" This was a 4-week randomized double-blind placebo-controlled study. Thirty-six married male patients with major depressive disorder whose depressive symptoms had been stabilized on fluoxetine and had subjective complaints of sexual impairment entered the study. The patients were randomly assigned to saffron (15mg twice per day) or placebo for 4weeks. International Index of Erectile Function scale was used to assess sexual function at baseline and weeks 2 and 4." Conclusions: Saffron is a tolerable and efficacious treatment for fluoxetine-related erectile dysfunction."
Hepatology Journal - American Ass.
Topic: Saffron and Heart Disease Protection
" Antioxidants in saffron tea can reduce the risk of cardiovascular diseases. The flavonoids, especially lycopene, found in saffron can provide added protection. A clinical trial at the Department of Medicine and Indigenous Drug Research Center showed positive effects of saffron on cardiovascular diseases. The study involved 20 participants, including 10 with heart diseases. According to the Indian Journal of Medical Sciences, all the participants showed improved health, but those with cardiovascular diseases showed more progress. In addition, saffron has been found to be the richest source of riboflavin. The blood and severity of atherosclerosis, thus reducing the chances of heart attacks. It may be one of the prime reasons that in Spain, where Saffron is consumed liberally, the incidence of cardiovascular diseases is quite low. The crocetin present in saffron is found to increase the yield of antibiotics. Two compounds of safranal are supposed to increase antibacterial and antiviral physiological activity in the body." * Cardiovascular Effects of Saffron: An Evidence-Based Review
Topic: Saffron as anti-cancer and anti-tumor
" Cancer continues to represent the largest cause of mortality in the world and claims over 6 million lives each year. An extremely promising strategy for cancer prevention today is chemoprevention, which is defined as the use of synthetic or natural agents (alone or in combination) to block the development of cancer in human beings. Plants, vegetables, herbs and spices used in folk and traditional medicine have been accepted currently as one of the main sources of cancer chemopreventive drug discovery and development. This review gives an overview from one of this herbs and spices that is saffron. The chemical composition of saffron has attracted the interest of several research groups during the last decades, and among the estimated more than 150 volatile and several nonvolatile compounds of saffron, approximately 40 – 50 constituents have already been identified. Oral administration of saffron extract inhibited the growth of mouse tumors that were derived from three different kinds of cancer cells and significantly increased the life spans of treated tumor-bearing mice." * Impact of saffron as an anti-cancer and anti-tumor herb
Topic: Saffron in the treatment of patients with mild to moderate Alzheimer's disease
Topic: Antioxidant Properties of Saffron
"The possible efficacy of saffron (Crocus sativus) in the management of memory loss. Saffron was found to be as effective as donepezil in the treatment of mild-to moderate Alzheimer disease.
Administration of saffron 30mg/day (15 mg twice daily) was found to be as effective as donepezil for treatment of mild to moderate Alzheimer Disease in the subjects of 55 years and older.
In another study, 46 patients of mild-to-moderate AD were treated by saffron for 16 weeks. The results showed that the cognitive function in saffron-treated group were significantly better than placebo * Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo-controlled trial"