of Ophthalmology, University Magna Graecia, Italy 2020
Topic: Astaxanthin in the Treatment of Ocular Diseases
Due to its unique molecular structure, astaxanthin features
some important biologic properties, mostly represented by strong antioxidant,
anti-inflammatory and anti-apoptotic activities. A growing body of evidence
suggests that astaxanthin is efficacious in the prevention and treatment of
several ocular diseases, ranging from the anterior to the posterior pole of the
eye. The efficacy of this carotenoid in the setting of retinal diseases, ocular
surface disorders, uveitis, cataract and asthenopia is reported in several studies,
which highlight its ability of modulating several metabolic pathways,
subsequently restoring the cellular homeostatic balance.
University, Birmigham, UK 2019
Topic: Saffron ( Crocus sativus L.) in Ocular
Diseases; age related macular
degeneration, glaucoma, diabetic , more
supplementation appears to have promising potential as an effective and safe
adjunct therapy in certain ocular diseases. (e.g., in age related
macular degeneration, glaucoma, and diabetic maculopathy).
Saffron (Crocus sativus L.) and its main
constituents, i.e., crocin and crocetin, are natural carotenoid compounds,
which have been reported to possess a wide spectrum of properties and induce
pleiotropic anti-inflammatory, anti-oxidative, and neuroprotective effects.
International Journal of Modular Science - Spain 2019
Topic: Saffron and Glaucoma
Scientifically shown daily supplementation with saffron with high crocin may protect retinal ganglion cell degeneration in the eye, decrease the intraocular pressure, and significant improvement in glaucomatous pathology.
of Ophthalmology, 2016
Topic: Zeaxanthin, and Lutein in Management of Eye Disease
Studies have reported that
increased dietary intake and higher serum levels of lutein and zeaxanthin are
associated with lower risk of age-related macular degeneration (AMD),
especially late AMD. Randomized, placebo-controlled clinical trials have
demonstrated that xanthophyll supplementation increases macular pigment levels,
improves visual function, and decreases the risk of progression to late AMD,
especially neovascular AMD. Current publications on the preventive and
therapeutic effects of lutein and zeaxanthin on cataracts, diabetic
retinopathy, and retinopathy of pre-maturity have reported encouraging results.
Research Council, Institute of Biophysics, Italy 2016
Topic: Saffron reduces ATP-induced retinal
cytotoxicity by targeting P2X7 receptors
studies demonstrated that saffron protects photoreceptors from light-induced
damage preserving both retinal morphology and visual function and improves
retinal flicker sensitivity in AMD patients.
It is involved in retinal neurodegenerative disorders such as retinitis
pigmentosa and age-related macular degeneration (AMD).
purinergic receptors are distributed throughout the nervous system where they
contribute to physiological and pathological functions. In the retina, this
receptor is found in both inner and outer cells including microglia modulating
signaling and health of retinal cells.
University of Medical Science - 2016
Saffron Supplement and AMD (Macular degeneration)
supplementation with saffron for 6 months significantly changes in macular OCT
and ERG parameters in patients with both dry and wet AMD, may induce a
mid-term, significant improvement in retinal function.
University of L’Aquila, Italy – 2014
Topic: Saffron and Retina
Clinical trial showed that in people with early AMD, dietary supplementation with saffron was able to significantly improve the retinal flicker sensitivity, suggesting a neuroprotective effect of the compound.
Published by: Journal of Opthalmol, 2012
Topic: Carotenoids in Age-related Maculopathy Italian Study (CARMIS)
two-year results of a randomized study
Because of the high concentration of carotenoids in the macula, as well as evidence linking oxidative stress to age-related macular degeneration (AMD) and carotenoids to antioxidation, studies shown that increasing antioxidant intake could help with macular de generation. The purpose of this study was to see if specific nutritional supplement improves visual acuity and visual function in people with AMD.
Subjects who received lutein/zeaxanthin and astaxanthin along with other nutrients were more likely to report clinically meaningful stabilization/improvement in VA, CS, and visual function after 24 months.
Immunology, Endocrine and Metabolic Agent in Medicinal
Topic: Effect of Multiple Dietary Supplement Containing Lutein, Astaxanthin on Accommodative Ability
A randomized double-blind placebo-controlled parallel group
comparison study was conducted for 48 participants aged 45 to 64 years who
complained of eye strain. The subjects took multiple dietary supplement
containing 10 mg of lutein 4 mg of astaxanthin. The multiple dietary supplement
group showed improvement in the NPA. Regarding subjective symptoms, significant
improvement of “stiff shoulders or neck” and “blurred vision” was also found in
the test supplement group compared to the placebo group. This study shows that
multiple dietary supplement containing lutein, astaxanthin has effect to
improve accommodative ability and subjective symptoms related to eye fatigue.
University of L’Aquila, Italy – 2010
Topic: Saffron and Loss of Sight